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Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)
Biotechnol Appl Biochem 68:14211431
Among 169,649 patients with MASLD, GLP-1 receptor agonist initiation was linked to significantly lower probability of incident cirrhosis [adjusted hazard ratio (aHR): 0.86, 95%CI: 0.80-0.93], hepatic decompensation (aHR: 0.77, 95%CI: 0.65-0.90), and hepatocellular carcinoma (HCC) (aHR: 0.79, 95%CI: 0.68-0.92) over a median follow-up of 3.5 years compared to non-users
Semaglutide, the active ingredient in popular drugs Ozempic and Wegovy, may also help people wean themselves off cocaine
Endocrinology 145(6):26802686
Prior drug treatments included antihyperlipidemic agents, antidiabetic agents, antiplatelet agents, antihypertensives, and other anti-obesity agents dispensed up to 24 months before the first dispensation of any GLP-1 RA
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