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Data from all statistical analyses are presented in Supplementary Table 1
The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells
Since none of the lysates showed any significant activity with NADH, it is unlikely that there is any transhydrogenase activity in erythrocytes, to reduce NADP+ to NADPH at the expense of NADH
Therefore, to delay this level of glycine production, the PepD construct (BBa_K3206007) was redesigned to have lower expression in an attempt to lower to amount of glycine the cell would be exposed to
Letter: Pellagra as the initial presentation of Crohn disease
