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In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

Symptoms include: Persistent fatigue and lack of motivation Decreased libido or erectile dysfunction Loss of muscle mass and strength Weight gain and slower metabolism Mood changes, irritability, and poor focus Reduced bone density A meta-analysis published in Clinical Endocrinology confirmed that TRT significantly increases lean body mass and decreases fat mass in hypogonadal men (Corona et al., 2016)

Possible Side Effects : Although rare, mild discomfort at the injection site may occur

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