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A minor fraction of APAP is metabolized by the cytochrome P450 system to produce N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive compound that can oxidize and damage essential cellular proteins
Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma
In conclusion, this study didnt even show that glutathione depletes zinc in yeast, but even if it did, it still wouldnt matter because of how radically different humans and yeast are