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any cloudiness may indicate aggregation or microbial contamination Visible particles or flocculation floating particles, fibres, or clumps are a clear sign the solution must not be used Discolouration any yellowing, browning, or colour change beyond the expected appearance described on the label warrants discarding the vial Gel-like consistency if the solution appears thicker than expected or does not flow freely, this may indicate peptide aggregation Do not open a sealed vial to assess odour
Wessells H, Levine N, Hadley ME, et al
Contact the dispensing pharmacy or prescriber before using it
A foundational 2005 study by Guideri et al
If you also want smoother texture and are treating pigment over time, tretinoin earns its place
What Does This Mean for Dental Professionals
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