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The permeability of the intestinal barrier can become elevated as a result of loose junctions, making it easier for microbes and dangerous antigens to penetrate and cause intestinal inflammation [71]

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Once mutant and/or misfolded proteins with a loss- or gain-of-function or damaged and potentially harmful cellular structures cannot be effectively eliminated, cells undergo malignant transformation, which may progress to carcinogenesis (Edinger and Thompson, 2003)

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