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(PubMed) George JD, Kim E, Spain R, Bourdette D, Salinthone S

As public insurance systems expand coverage, however, the markets key competitive factors are likely to shift toward pricing and accessibility

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The main concerns include additive gastrointestinal effects (nausea, vomiting, diarrhoea), cognitive side effects from topiramate (difficulty concentrating, memory problems), and potential for excessive weight loss

FOS, FOS Proto-Oncogene, AP-1 Transcription Factor Subunit

Moreover, a GLP-1 analog, (Val(8))GLP-1-Glu-PAL, increased hippocampal neurogenesis and cell proliferation in obese mice fed a high-fat diet (Lennox et al., 2013)