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The appetite stimulation is directly mediated by ghrelin receptor activation in the hypothalamic arcuate nucleus, activating neuropeptide Y and agouti-related peptide neurons that drive feeding behavior

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2.5 Experimental verification of computationally predicted spray performance To extrapolate to real-world spray performance that could be projected from the in silico framework, we linked the computationally predicted nasopharyngeal droplet deposition efficiencies with the size distribution of droplets (see Figure 5) in two existing over-the-counter spray productsthus assessing the expected deposition at the nasopharynx with a typical nasal spray