In a study published in the Journal of Cutaneous and Aesthetic Surgery, the maximum dose used in one sitting was 5 g (6)
MIDDLE EAST GLUTATHIONE MARKET SIZE, BY REDUCED GLUTATHIONE, 2018-2032 (USD MILLION) TABLE 345
Proc Natl Acad Sci U S A 91:12614, PMID: 8108398 Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, Ohtsuka E, Nishimura S (1987) Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
Unexpected role of adenosine-monophosphate activated protein kinase in doxorubicin cardiotoxicity and metformin-mediated cardioprotection
9% use it for 45+ days[] These safe therapeutic doses can significantly deplete glutathione in women who already have low baseline levels.[] Healthy individuals can tolerate up to 4g/day with only modest glutathione decrease, but individuals with compromised glutathione experience significant depletion even at therapeutic doses
These complementary biological activities have generated widespread scientific interest in regenerative medicine and connective tissue biology