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Side Effects Gastrointestinal Issues: Nausea, vomiting, and diarrhea are the most common, especially during the first few weeks

PKA and EPAC are activated by elevated cAMP

While overall prescribing of semaglutide increased throughout second quarter of 2024, the rate of first-time prescribing of semaglutide slowed from 0.9% of prescriptions in May 2024 to 0.7% in June 2024

Hyposalivation, a related but distinct condition, refers to objectively reduced salivary flow, typically measured at less than 0.1 mL per minute for unstimulated whole saliva

Another Unexpected GLP-1 Side Effect: Vision Problems Bone health is not the only concern

Weekly Dosing Both are generally administered once weekly with gradual dose escalation