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[6] At anticholinergic doses it also antagonizes muscarinic M receptors, potentiating drying of secretions, mydriasis, tachycardia, and decreased gastrointestinal motility
hypo/hyperreflexia
FDA has also given breakthrough status to idarucizumab, an antidote to its drug, Pradaxa
Most of the mutations in SLC22A5 are missenses mutations but nonsense, splice site, and deletion/insertion mutations have also been identified
Fras JP et al
Spironolactone and alcohol Caution is advised when drinking alcohol while taking spironolactone
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