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It should further be noted that there are examples of digital private clinics with a niche for weight-loss treatment that started in 2021 [71], and these most probably affected the rise of GLP-1 RAs observed after 2021

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In this Review, we summarize the data from CVOTs of GLP1R agonists in patients with T2DM and describe the actions of GLP1R agonists on the heart and blood vessels