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About orforglipron Orforglipron (or-for-GLIP-ron) is an investigational, once-daily small molecule (non-peptide) oral glucagon-like peptide-1 receptor agonist that can be taken any time of the day without restrictions on food and water intake
Although the funnel plots indicated no publication bias, the variability in the findings calls for caution in interpreting the overall effectiveness of GLP-1RAs under these parameters
DISCLOSURES: The study authors disclosed having no relevant financial relationships.
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Furthermore, high glucose levels increase the formation of advanced glycation end products (AGEs) through the non-enzymatic reaction between reducing sugars and cellular proteins, lipids, or nucleic acids
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