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Tesamorelin stimulates a GH pulse through the pituitary, and GH release is closely linked to sleep onset pathways

New England Journal of Medicine, 349(17), 1605-1613

Restarting at a higher dose with anti-nausea medication such as ondansetron may be an option for so

Dose escalation should follow standard protocols, typically starting with 0.25 mg weekly for injectable semaglutide and increasing gradually every four weeks as tolerated

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However, if nausea occurs with weekly formulations, it may persist longer due to the extended half-life