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Hormone Replacement Therapy delivers hormones directly, while peptides signal the body to adjust its own processes

For Western blotting, proteins were transferred to a nylon membrane, probed with an anti-GPx4 antibody and -actin (Abcam, ab231174), and detected with HRP-conjugated secondary antibodies

P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells

Hoxie, Mary E