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This creates a constant demand for antioxidants

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After ferroptosis, excess intracellular free iron can enter the mitochondria, resulting in smaller myocardial mitochondria, increased mitochondrial membrane density, decreased mitochondrial respiration, and mitochondrial membrane potential depolarization (Sumneang et al., 2020), thus inducing CD and a series of Cardiac Diseases such as arrhythmia (Hu et al., 2021)

Table 8

no OTC supplement has matched a fraction of that in any published trial (2025 joint advisory, ACLM/ASN/OMA/TOS)