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Afterward, each woman self-administered a single-blind, placebo dose in a clinical setting, supervised by research staff, followed by a one-week monitoring period

**In a clinical study of 27 women after 8 weeks

Research protocols sometimes combine matrikine signals with broader gene modulators to address both the targeted collagen induction pathway and the broader tissue remodeling network simultaneously

Data availability Uncropped western blot images are provided in Supplementary Fig

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Many peptides discussed in anxiety research remain investigational and may not be approved specifically for anxiety treatment in many countries