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The prevalence of diverticular disease in the UK is estimated at 5% in those under 40, rising to over 50% in those over 70, according to NICE Clinical Knowledge Summary (CKS)
All three target Glutathione levels, but have different mechanisms and potential benefits
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
Evolocumab belongs to the class of medications called PCSK9 inhibitors
Analysis showed that the trial met its primary endpoint of achieving a superior mean percent change in body weight with tirzepatide versus placebo from week 36 to week 88, with patients sustaining weight loss
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