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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

For most research protocols, 4-6 sprays per day are needed

Enzyme inhibitor peptides directly or indirectly impede the activity of enzymes, while soybean peptide inhibits the formation of proteinase

If markers remain stable and small improvements appear they continue with periodic checks

Weakening of the endogenous antioxidant system leads to uncontrolled ROS production that outweighs the antioxidant capacity of the brain, causing developmental neurotoxicity

R.et al (2011a)