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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

Slow breathing with a long exhale can ease cramps and lower urgency

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Episodes may occur suddenly, often alongside dizziness, palpitations, fatigue, or brain fog, and may improve when lying down

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