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hTERT transcription is governed by a complex promoter region approximately 330 base pairs upstream of the transcription start site, containing binding sites for activating transcription factors (c-Myc, Sp1, HIF-1, estrogen receptor elements) and repressors (WT1, p53, Menin, Mad1)
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Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers
304 Moreover, targeting the metabolic and epigenetic axes by modulating cofactors such as acetyl-CoA, S-adenosylmethionine (SAM), or -ketoglutarate (-KG) offers a means to indirectly reprogram aberrant chromatin states
PMID 37364590
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