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Rapid weight loss increases gallbladder risk regardless of how that weight loss is achieved

[21] [22] Patients with pre-existing gastroparesis or severe gastrointestinal disease were excluded from major clinical trials, and the FDA label specifically states that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

But what I think is missing from the conversation is the side effects. These are common and unpleasant

Together, the cumulative effect on heart rate and blood pressure becomes clinically significant, particularly for patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias

Zhao, H., Zhang, Q., Zhao, L., Huang, X., Wang, J., & Kang, X