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347 After the development of first-generation SERMs tamoxifen and second-generation SERMs toremifene and raloxifene, several novel endocrine therapy drugs are currently under development to enhance efficacy and reduce toxicity
Additionally, obesity itself can contribute to gut dysbiosis, creating a vicious cycle
The observations potentially support the supposition that the rise in cortical and total BMC might be due to enhanced bone growth resulting in increased bone dimensions, while the volumetric BMD remained unchanged
[36] Jayaram, L., King, P.T., Hunt, J., Lim, M., Park, C., Hu, E