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Conjugation of a fatty acid chain via hydrophilic linkers to lysine residue at the C20 position prolongs its half-life and enables onceweekly subcutaneous administration [62]

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BergenstalRMWyshamCMacconellLMalloyJWalshBYanPet al

Nauck MA, Siemsglss, rskov C, Holst JJ

Abstract The Glucagon-like peptide-1 receptor (GLP-1R) is a member of the class B G protein-coupled receptor (GPCR) family and a well-established target for the treatment of type 2 diabetes