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Its supplementation elevates NAD + , activating SIRT1 to regulate metabolism and suppress neuroinflammation ( 4.5 Limitations and future directions Limitations of the present study include incomplete recapitulation of human SAE heterogeneity by CLP and the lack of Nrf2 knockout/GSH inhibitor validation

Propagation of lipid peroxidation Lipid peroxidation is both a marker and mediator of ferroptosis (26)

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Age-related declines have been observed in multiple tissues and experimental models, but the amount varies by tissue, measurement method, health status, and study

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