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Hill MH, Flatley JE, Barker ME, et al

PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

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An increased F2-isoprostane result may reflect smoking, metabolic dysfunction, inflammation, or another source of oxidative activity