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A phase 2, 16-week, open-label study in 18 subjects ranging from 6 to 40 years of age results in a mean BMI reduction of 18% in those younger than 18 years, and 6% for those 18 years or older, accompanied by significant reduction of hunger scores (127)

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

doi: 10.3390/biom10010084 2

As we age, the regulation of gene expression becomes less precise

PLoS ONE 9:e109841 Pang MD, Goossens GH, Blaak EE (2021a) The impact of artificial sweeteners on body weight control and glucose homeostasis

It should be noted that while the HIF pathway can induce antioxidant genes like SOD2 to maintain adaptive balance under acute hypoxia, this protective effect in chronic diseases like cancer may conversely aid malignant cells in resisting apoptosis, constituting another dimension of intervention complexity [501]