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Semaglutide acts on multiple systems simultaneously: Brain signaling: It activates GLP-1 receptors in the hypothalamus, reducing hunger signals and promoting fullness after smaller meals
Phase 1 (weeks 14) involves appetite reduction and early water weight loss
It typically subsides within minutes and does not indicate an unsafe dose or faulty medication
Its not as high of weight loss as tirzepatide and not as high as some of the things that well see coming down the pipeline in the next six months to a year, but I think theres room for all of those [medications], says Deborah Horn, director of obesity medicine at UTHealth Houston, who led the most recent trial on Foundayo
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