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Cancer Res 64 : 236242 Girnita L, Girnita A, Brodin B, Xie Y, Nilsson G, Dricu A, Lundeberg J, Wejde J, Bartolazzi A, Wiman KG, Larsson O (2000) Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact
Minoxidil provides relatively quick initial results because it leverages existing follicular machinery, but its effects remain localized to the application site and require continuous use
Thus, modulating the Fc:FcRn interaction to prolong plasma half-life and attain a favorable biodistribution is a clinical success, and several clinical-stage candidate therapeutics harbor either the YTE or LS amino acid substitutions, or a more recently reported triple Fc mutant variant (Q311R/M428E/N434W
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