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Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly GLP1 2.4 mg in type 2 diabetes: A multicentre, randomised, double-blind, active-controlled, phase 2 trial

The sustained tonic GH/IGF-1 elevation it produces rather than pulsatile bursts is both a research advantage (easier to measure steady-state changes in body composition) and a design consideration (it does not replicate physiological GH pulsatility, which may matter in neuroendocrine studies)

A.Moss-MorrisR

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Glucose and HbA1c are monitored throughout the cycle

Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics