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FPN1 functions in concert with ferroxidases such as HEPH and CP, which oxidize Fe 2+ to Fe 3+ , enabling its safe release into the systemic circulation (Zhou and Tan, 2017)

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These findings demonstrate that sulforaphane robustly activates NRF2 in the cerebellum and peripheral tissues, protecting them from oxidative stress and leading to a reduction in autism-like behaviors (Nadeem et al., 2019)