Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care
Several lines of research suggested that breakdown to the integrity of the bloodbrain barrier (BBB) and subsequent brain penetration of serum components and cytokines is responsible for the neurological manifestations after SARS-CoV-2 infection 17,18
Analysis of effectiveness of treatment (main outcome) at the three monitoring points Intention-to-treat and per-protocol analyses will both be performed, as is recommended for non-inferiority studies [38]
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BPC-157 supports muscle recovery after injury by accelerating the transition from the inflammatory phase to the proliferative phase of healing