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Before the trafficking and release of the RP granules occur, granule competency must be achieved, and this is believed to occur through granule acidification resultant from an increase of H + and Cl ions and processing of pro-insulin into mature, releasable, insulin (36)
This resolves quickly once consistent dosing resumes
(to D.G.P.), the Swiss National Science Foundation Postdoc Mobility fellowship (to D.H.) and the DGIST Start-up Fund Program of the Ministry of Science (ICT 2025020055 to S.-Y.L.)
: , : 13 2026 .
Any molecular or cellular observations reported vary with the experimental model, peptide concentration, exposure time and methodological conditions
doi: 10.1007/s00125-010-2028-x 168 LiljedahlLPedersenMHMcGuireJNJamesP
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