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This led to their marketing for obesity and metabolic health
The mRNA expression of TGF-1 , a known anti-inflammatory factor, was significantly increased by dietary L-carnitine supplementation in the muscle in the feeding and fasting states
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Consistently, AMPK activator AICAR was attenuated, while PARP-1 over-activation aggravated cholesterol-induced toxicity in INS-1 cells, indicating that in islet cells, PARP-1 also regulates cholesterol efflux through AMPK activation and ABCA1 protein, therefore affecting the GLP-1 protection against cholesterol-induced toxicity
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