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Methods Protocol The study protocol for the present systematic review was first published 23 January 2021 in the PROSPERO database, Protocol deviations The following deviations from the initial protocol were necessary and were amended in a protocol update: the search strategy was updated to include Embase and Cochrane

While the maximum dose is 15 mg, most patients will not need to get to this dose

87%, respectively), and in the subgroup of children with developmental delay, cerebral palsy, and intellectual disability the percentage of failure after Mel was higher ( Both Mel and Dex were safe to use and none of the participants experienced any significant side effects

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Sporadic application doesn't deliver cumulative signaling effects