the second contraction occurs during the phase of propulsion [51, 52]
The pill can't be crushed, cut, chewed, or dissolved: it needs to be swallowed whole
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Starting aggressive titration without this experience dramatically increases failure rates
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Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S et al (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1