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The idea: escalate to 9-12mg for initial weight loss, then step down to 4mg for long-term maintenance

and secondary stimulation (associated with activation in neighbouring areas, rather than influence on GLP-1Rs) of C-Fos neurons in the thalamic nuclei and CGRP neurons in the parabrachial nuclei

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Peripherally administered GLP-1R and GIPR agonists have also been shown to localize in CVOs, with limited labelling in brain regions shielded by the bloodbrain barrier 13,54,55

TRAINA: We took out a couple of amino acids and exchanged them for other ones so that the molecule can't immediately be degraded by the enzyme that our body naturally makes to break it down

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