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This ratio is actually comparable to or slightly better than what is seen with aggressive diet-only interventions, but it is still a meaningful amount of muscle to lose

We quantified the immobility time (in seconds) of the mice during the final 4 min of the test

PhilisTsimikas et al., 2019

While exposure to long-term therapy is of potential concern, it is uncertain whether drug exposure to GLP-1 receptor agonist therapies for shorter durations is of any clinical consequence 28

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GLP-1 users typically need 1.0-1.6 grams of protein per kilogram of body weight daily to preserve muscle mass, and most fall far short of this target