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High-dose semaglutide (7.2mg weekly) represents another near-term development
In rats, GCLC has a Km for glutamate that is about 10-fold higher, which is higher than the cellular glutamate concentration in most tissues
But it creates sticker shock for patients who budgeted based on the first month number
The dual agonism targets both GIP and GLP-1 pathways, which are key incretin hormones involved in glucose regulation
Minimize this risk by cleaning the rubber stopper with an alcohol swab before every draw, using a new sterile needle and syringe each time, not touching the needle to any surface before inserting it into the vial, and drawing the dose in a clean environment (not a dusty garage or outdoor setting)
The Phase 2 dose-finding trial randomized 706 adults with overweight or obesity across 57 sites in 10 countries
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