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The Cons of Covering GLP-1s High and Ongoing Costs GLP-1 medications can cost $1,000+ per month per person
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Research-grade peptides, including ours, are not FDA-approved and are sold for research purposes only
It works through several mechanisms: Appetite regulation : Semaglutide acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing hunger and increasing satiety after meals Delayed gastric emptying : It slows the rate at which food leaves the stomach, prolonging feelings of fullness (this effect may be most pronounced during dose escalation) Glucose-dependent insulin secretion : In the presence of elevated blood glucose, it stimulates pancreatic beta cells to release insulin Glucagon suppression : It reduces inappropriate glucagon secretion from pancreatic alpha cells, thereby limiting hepatic glucose production These combined effects result in significant weight lossaround 15% of body weight in people without diabetes and approximately 9-10% in people with type 2 diabetes, according to clinical trialsand improved glycaemic control in people with type 2 diabetes
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Ultimately, prospective studies evaluating bone outcomes with different GLP-1 RAs in this population, incorporating standardized DXA assessments and fracture surveillance, are needed to establish evidence-based skeletal health guidelines
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