melanotic macule histology Lingual – the first case report in an adult patient* Histomorphometric and Immunohistochemical Characteristics of

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It contains a combination of glutathione, N-acetylcysteine, vitamin C and selenium

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The melanotic macule typically appears as a small, well-circumscribed, brown-to-black flat macule on the lip or mucous membranes, caused by increased melanin in the basal layer

Meanwhile, the results of Western blot assay showed that the protein expression levels of Cyclin A2 , Cyclin E2 , c-MYC , Cyclin D1 and CDK2 were significantly increased in the RRM2 overexpression group, and Cyclin D1 , Cyclin E1/E2 and Cyclin A2 are important regulators driving the cell cycle process, and their high expression is often associated with the acceleration of G1/S phase transition