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For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity
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HUBERMAN: One of the reasons why it's being used so extensively is that it does seem to have very high safety profiles, at least with respect
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[22] B 12 deficiency in pregnant women is increasingly common [23] and has been shown to be associated with major maternal health implications, including increased obesity, [23] higher body mass index (BMI), [24] insulin resistance, [22] gestational diabetes, and type 2 diabetes (T2D) in later life
