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The neurotoxic effects of excessive glutamate include the overactivation of both ionotropic and metabotropic glutamate receptors, which leads to a substantial influx of Ca 2+ into cells, resulting in apoptosis and necrosis (Lai et al., 2014)
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That said, its not recommended for people with a history of pancreatitis or severe gastrointestinal issues
The perturbation of cellular glutathione homeostasis was achieved by exposing hepatocytes to H 2 O 2 , which is a well-established method of inducing intracellular glutathione imbalance
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