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Similar content being viewed by others 1 Introduction Magnetic nanoparticles (NPs) have been widely investigated and utilized in the last decades [1,2,3,4], due to their different applications in different fields such as, biotechnology [5], catalysis [6], wastewater treatment [7], optoelectronic [8] and biomedicine [9, 10]

For oral administration, clinical trials have studied doses ranging from 1-30 mg daily, with typical protocols using 1-2 mg per dose on an empty stomach

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It is known that STAT3/SOCS signaling can promote cellular senescence by activating the p53-induced gene expression [10, 150]

However, shockwave therapy alone has been shown to be highly effective in the acute phase of the penile trauma and moderately effective after the plaque has fully formed