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Sustainable lifestyle changes: members adopt and sustain healthier habits while the solution ensures therapeutic graduation to more holistic lifestyle practices The solution will be available to early adopter employers in 2025, with plans to continue to expand Premier Pharmacy to address additional high-cost, high-priority pharmacy needs for employers
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Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with type 2 diabetes (73.1% with prior cardiovascular disease) and followed them for a median of 3.2 years: Primary MACE endpoint : HR 0.91 (95% CI 0.83-1.00), p=0.06 for superiority Met non-inferiority but narrowly missed superiority (p=0.06) All-cause mortality was reduced by 14% (HR 0.86, p=0.016) in a secondary analysis EXSCEL confirmed cardiovascular safety but did not prove cardiovascular benefit -- a critical distinction
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It helps the body by triggering insulin, reducing blood sugar, delaying the stomach from emptying, and telling the brain when youre full
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