The temperature-humidity index (THI) was calculated [THI = T (0.31 0.31 RH) ( T 14.4)] following a previous study that described the relationship between sheep heat-stress and meteorological conditions ( Experimental Protocol As explained in Figure 1, heat-stressed rams ( n = 15) were examined sonographically either by spectral Doppler for the supra-testicular artery of the right and left testis and B-mode scanning of the testicular parenchyma or blood sampling just before (0 h) treatment with LC
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doi: 10.1016/j.bbacli.2016.05.006 26 SaundersJ
The supplemental approval is based on data from the Phase III PhALLCON trial, in which treatment with Iclusig led to superior MRD-negative complete remission rates and had comparable safety to Novartis Gleevec in adults with newly diagnosed Ph+ ALL