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While endogenous GLP-1 acts as an inhibitor of glucagon secretion during hyperglycemic episodes, some studies indicate that exogenous GLP-1 exerts a stimulatory effect on glucagon secretion during hypoglycemia in healthy individuals [34, 35]
Blood sugar levels may also rise, especially in patients with Type 2 diabetes
Both companies have asked the FDA to ban compounding of their drugs, saying that the substances are too complicated to make using those methods
The GLP-1 component of tirzepatide may also contribute by slowing gastric emptying and potentially affecting gallbladder motility
doi:10.1038/ejcn.2011.59 Safer choice
Not in an FDA-approved version
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