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In this trial, 3,183 adult patients with inadequately controlled type 2 diabetes mellitus and atherosclerotic CV disease were randomized to RYBELSUS 14 mg once daily or placebo for a median observation time of 16 months
Combining two metabolically active agents that influence body composition and hormonal signalling introduces a range of potential safety concerns, even when each drug is used individually within its intended parameters
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Since in some of the studies analysed type 2 diabetic patients were treated with metformin, which has been shown to enhance GLP-1 responses [51], any potential difference in GLP-1 secretory responses between type 2 diabetic patients and healthy participants may have been modified by this mechanism
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