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The pattern of consistent findings across in vitro, ex vivo, and animal-model contexts has shaped the contemporary research-context framing for the compound
Welsh SJ, Bellamy WT, Briehl MM, Powis G (2002) The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
Weight loss results vary widely