A brand called Supergut touts prebiotics as natures Ozempic in its marketing and claims that its products trigger your bodys hunger-quieting GLP-1 hormone naturally. The supplement brand Pendulum offers a GLP-1 Probiotic, which it also claims helps increase GLP-1 production naturally. Other lines, like Codeage, offer blends like the GLP Advantage+, which contains L-taurine, decaffeinated green tea leaf extract, boron, prebiotics, and a variety of other ingredients, including berberine, an antibiotic-like ingredient popular with wellness influencers on TikTok who tout its appetite-suppressing properties
The following features would enhance the value of an obesity therapeutic, but would likely be assessed in follow-up trials or even post-approval: Additional efficacy in obesity-related co-morbidities
Peptic ulcers, severe gastritis, or esophageal varices are common causes
The Bureau of Customs in Manila seized over 53 million worth of counterfeit drugs shipped from China that were falsely declared as pet cages
Concerning the species used in Pendulums products, most of them have been found to impart health benefits at much lower quantities: 1 million CFU8 Clostridium butyricum: 10 million CFU in animal models9 Clostridium beijerinckii: 100 million CFU in animal models10 Anaerobutyricum hallii (formerly Eubacterium hallii ): 100 million CFU11 Bifidobacterium infantis: 100 million CFU12 Akkermansia muciniphila: Theres no direct translation between CFU and AFU, but these numbers should give you a sense of Pendulums efficacy with respect to viable bacterial quantity
These medications, while helpful for these conditions, could indirectly cause fluid or electrolyte imbalances